We had the same problem when we added 5 month old Harley to our family last November. From day one he was very sick (got him from the city shelter) and would not use the litter box. I would first recomend that there was not medical problems. Our vet suggested that we put him in a small kennel with food and a small litter box. Once he learned to use the litter box only (took about 1 1/2 weeks) he graduated to the spare bathroom with again only the food and small litter box. Once he mastered that (about another week) he moved to the spare bedroom with his litterbox and food (about 5 days. Then he was allowed in the rest of the house. We have never had a problem after that. I was so afraid that we were going to have to give him up, something I would never normally do as a cat lover but I was pregnant at the time and could not have a baby crawling around a house with the kitty going whereever. It was hard to have him in the kennel and rooms for so long and hear his little kitten cries but it was worth it in the long run. You have to stay strong and determined! Good luck!